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Article

Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

25 Oct 2011

Abstract excerpt

PURPOSE: Polycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers. This study was undertaken to examine the frequency and clinical relevance of PcG protein expression in malignant pleural mesotheliomas (MPM). EXPERIMENTAL DESIGN: Microarray, quantitative reverse transcriptase PCR (qRT-PCR), immunoblot, and...

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PMID: 22028491
DOI: 10.1158/1078-0432.ccr-11-0962

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