Article
An analysis of insulin receptor expression and binding on MHC class I positive and negative human lymphoblastoid cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1990
Liegler T, Alexander J, Cresswell P, Goldfine I, Goodenow R S
Abstract excerpt
Recent studies have demonstrated a specific membrane association between the polymorphic class I antigens of the MHC and the insulin receptor (IR). In some reports, variation in IR binding is attributed to the class I phenotype. To extend these observations, we have examined whether MHC class I products influence IR function, in particular, high affinity ligand-specific binding. Using two independent methods, we...
Topics
- Cell Line
- Histocompatibility Antigens Class I
- Humans
- In Vitro Techniques
- Insulin
- Lymphocytes
- Mutation
- Radioimmunoassay
- Radioligand Assay
- Receptor, Insulin
- Recombinant Proteins