Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced biological effects of Phe140Asn, a novel human granulocyte colony-stimulating factor mutant, on HL60 cells.

BMB reports - 1 Oct 2011

Chung Hee Kyoung, Kim Sung Woo, Byun Sung June, Ko Eun Mi, Chung Hak-Jae, Woo Jae-Seok, Yoo Jae Gyu, Lee Hwi-Cheul, Yang Byoung-Chul, Kwon Moosik, Park Soo-Bong, Park Jin-Ki, Kim Kyung-Woon

Abstract excerpt

Granulocyte colony-stimulating factor (G-CSF) is a cytokine secreted by stromal cells and plays a role in the differentiation of bone marrow stem cells and proliferation of neutrophils. Therefore, G-CSF is widely used to reduce the risk of serious infection in immunocompromised patients; however, its use in such patients is limited because of its non-persistent biological activity. We created an N-linked...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotactic Factors
Share to Granulocyte Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HL-60 Cells

Share to Inhibitor of Apoptosis Proteins

Share to Janus Kinase 2

Share to Neutropenia

Share to STAT3 Transcription Factor

Share to Survivin

Source

Identifiers

PMID: 22027004
DOI: 10.5483/BMBRep.2011.44.10.686

Genes

JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced biological effects of Phe140Asn, a novel human granulocyte colony-stimulating factor mutant, on HL60 cells.PMID 22027004Read ↗

The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease.Semantic proximity Read ↗

Advances in understanding postreceptor signaling in response to granulocyte colony-stimulating factor.Semantic proximity Read ↗

G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells.Semantic proximity Read ↗

O-linked sugar chain of human granulocyte colony-stimulating factor protects it against polymerization and denaturation allowing it to retain its biological activity.Semantic proximity Read ↗

GIFT4 fusokine converts leukemic B cells into immune helper cells.Semantic proximity Read ↗

[G-CSF and Its Receptor in Hematonosis].Semantic proximity Read ↗

The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4.Semantic proximity Read ↗

A novel homozygous VPS45 p.P468L mutation leading to severe congenital neutropenia with myelofibrosis.Semantic proximity Read ↗

Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia–derived Mutation in the G-CSF Receptor GeneSemantic proximity Read ↗

Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells.Semantic proximity Read ↗

Screening for novel constitutively active CXCR2 mutants and their cellular effects.Semantic proximity Read ↗

Clone and expression of mutant M-CSF and its receptor from human leukemic cell line J6-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.