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Article

Additive effect of GHRd3 and COLIA1 polymorphisms on the GH-substitution dose in GH-deficient adults.

Pharmacogenomics - 1 Dec 2011

Hartleb Silke, Plöckinger Ursula, Stalla Günter K, Tuschy Ulrich, Weber Matthias M, Pfützner Andreas, Kann Peter Herbert

Abstract excerpt

UNLABELLED: The exon 3-deleted/full-length growth hormone receptor (GHRd3) polymorphism and the collagen type Iα 1-specific protein 1 (COLIA1) polymorphism have each recently been linked to the responsiveness to recombinant growth hormone (GH) treatment in GH-deficient adults. In this context, one or two GHRd3 alleles and the homozygous COLIA1 TT genotype were each associated with a significantly lower GH dose....

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Share to Collagen Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Dwarfism, Pituitary

Share to Hormone Replacement Therapy

Share to Human Growth Hormone

Share to Insulin-Like Growth Factor I

Share to Recombinant Proteins

Source

Identifiers

PMID: 22026923
DOI: 10.2217/pgs.11.113

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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