Article
Mutation region detection for closely related individuals without a known pedigree using high-density genotype data.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2012
Ma Wenji, Yang Yong, Chen Zhi-Zhong, Wang Lusheng
Abstract excerpt
The fundamental problem in linkage analysis is to identify regions whose allele is shared by all or almost all affected members but by none or few unaffected members. Almost all the existing methods for linkage analysis are for families with clearly given pedigrees. Little work has been done for the case where the sampled individuals are closely related, but their pedigree is not known. This situation occurs very...
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