Article

Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation

2025-04-29

Abstract excerpt

<title>Abstract</title> <p> Osteoporosis is a multifactorial disease, and emerging evidence suggests that iron overload contributes to its progression. Here, we identify Lipocalin-2 (LCN2), a cytokine secreted by bone cells with endocrine effects on other tissues, as a local regulator of osteocyte iron metabolism and a mediator of skeletal deterioration. Our findings reveal that LCN2 promotes iron accumulation,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98338742-1506-59b7-860c-b36c6948b388
DOI: 10.21203/rs.3.rs-6430607/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone FormationDOI 10.21203/rs.3.rs-6430607/v1Read

Lipocalin-2 expression in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesisSemantic proximity Read

A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism.Semantic proximity Read

Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis.Semantic proximity Read

Ferroptosis: A New Regulatory Mechanism in OsteoporosisSemantic proximity Read

Lipocalin 2 Influences Bone and Muscle Phenotype in the MDX Mouse Model of Duchenne Muscular Dystrophy.Semantic proximity Read

LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment.Semantic proximity Read

Transcriptomic and bioinformatic analysis of Clcn7-dependent Autosomal Dominant Osteopetrosis type 2. Preclinical and clinical implications.Semantic proximity Read

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization.Semantic proximity Read

Overview of the expression patterns and roles of Lipocalin 2 in the reproductive systemSemantic proximity Read

Structure, Functions, and Implications of Selected Lipocalins in Human DiseaseSemantic proximity Read

ASXL2 Regulates Glucose, Lipid, and Skeletal HomeostasisSemantic proximity Read

A Population of M2 Macrophages Associated With Bone Formation.Semantic proximity Read