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Article

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction.

Autophagy - 1 Dec 2011

Alers Sebastian, Löffler Antje S, Paasch Florian, Dieterle Alexandra M, Keppeler Hildegard, Lauber Kirsten, Campbell David G, Fehrenbacher Birgit, Schaller Martin, Wesselborg Sebastian, Stork Björn

Abstract excerpt

Under normal growth conditions the mammalian target of rapamycin complex 1 (mTORC1) negatively regulates the central autophagy regulator complex consisting of Unc-51-like kinases 1/2 (Ulk1/2), focal adhesion kinase family-interacting protein of 200 kDa (FIP200) and Atg13. Upon starvation, mTORC1-mediated repression of this complex is released, which then leads to Ulk1/2 activation. In this scenario, Atg13 has...

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Identifiers

PMID: 22024743
DOI: 10.4161/auto.7.12.18027
PMCID: PMC3327613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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