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Article

Identification and structural characterization of novel genetic elements in the HIV-1 V3 loop regulating coreceptor usage.

Antiviral therapy - 1 Jan 2011

Svicher Valentina, Alteri Claudia, Artese Anna, Zhang Jing Maria, Costa Giosuè, Mercurio Fabio, D'Arrigo Roberta, Alcaro Stefano, Palù Giorgio, Clementi Massimo, Zazzi Maurizio, Andreoni Massimo, Antinori Andrea, Lazzarin Adriano, Ceccherini-Silberstein Francesca, Perno Carlo Federico

Abstract excerpt

BACKGROUND: The interaction between HIV-1 gp120 and CCR5 N terminus is critical for R5-virus entry and affects CCR5 antagonists' activity. Knowledge of how different genetic signatures of gp120 V3 domain effect the strength of this interaction is limited. METHODS: HIV-1 coreceptor usage was assessed in 251 patients using enhanced-sensitivity Trofile assay and V3 sequencing plus tropism prediction by Geno2pheno...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22024519
DOI: 10.3851/IMP1862

Genes

CCR5
CXCR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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