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Article

HIV-1 gp120 V3 Loop for Structure-Based Drug Design

30 Sept 2005

Abstract excerpt

HIV-1 cell entry is mediated by sequential interactions of the envelope protein gp120 with the receptor CD4 and a coreceptor, usually CCR5 or CXCR4, depending on the individual virion. Considerable efforts on exploiting the HIV coreceptors as drug targets have led to the new class of coreceptor antagonists. While these antiretroviral drugs aim at preventing virus/coreceptor interaction by binding to host...

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PMID: 16248793
DOI: 10.2174/138920305774329359

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