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Article

Site-specific mutagenesis of PRD1 DNA polymerase: mutations in highly conserved regions of the family B DNA polymerase.

Biochemical and biophysical research communications - 16 Aug 1990

Jung G H, Leavitt M C, Schultz M, Ito J

Abstract excerpt

The PRD1 DNA polymerase is a small multifunctional enzyme containing three major conserved amino acid sequences shared by family B DNA polymerases. Thus, the PRD1 DNA polymerase provides an useful model system with which to study structure-function relationships of DNA polymerase molecules. In order to investigate the functional and structural roles of the highly conserved amino acid sequences, we have introduced...

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PMID: 2202298
DOI: 10.1016/0006-291x(90)90534-t

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