Article
Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation.
PloS one - 1 Jan 2011
Yao Song, Sucheston Lara E, Smiley Shannon L, Davis Warren, Conroy Jeffrey M, Nowak Norma J, Ambrosone Christine B, McCarthy Philip L, Hahn Theresa
Abstract excerpt
BACKGROUND: Bone mineral density (BMD) loss commonly occurs after hematopoietic cell transplantation (HCT). Hypothesizing that genetic variants may influence post-HCT BMD loss, we conducted a prospective study to examine the associations of single nucleotide polymorphisms (SNP) in bone metabolism pathways and acute BMD loss after HCT. METHODS AND FINDINGS: We genotyped 122 SNPs in 45 genes in bone metabolism...
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