Article
Comparison of gene expression and genome-wide DNA methylation profiling between phenotypically normal cloned pigs and conventionally bred controls.
PloS one - 1 Jan 2011
Gao Fei, Luo Yonglun, Li Shengting, Li Jian, Lin Lin, Nielsen Anders Lade, Sørensen Charlotte Brandt, Vajta Gábor, Wang Jun, Zhang Xiuqing, Du Yutao, Yang Huanming, Bolund Lars
Abstract excerpt
Animal breeding via Somatic Cell Nuclear Transfer (SCNT) has enormous potential in agriculture and biomedicine. However, concerns about whether SCNT animals are as healthy or epigenetically normal as conventionally bred ones are raised as the efficiency of cloning by SCNT is much lower than natural breeding or In-vitro fertilization (IVF). Thus, we have conducted a genome-wide gene expression and DNA methylation...
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