Article
Hierarchical phenotypic and epigenetic variation in cloned swine.
Biology of reproduction - 1 Aug 2003
Archer Greg S, Dindot Scott, Friend Ted H, Walker Shawn, Zaunbrecher Gretchen, Lawhorn Bruce, Piedrahita Jorge A
Abstract excerpt
Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profiles of selected genomic regions. Phenotypic and genetic analyses indicated that there are two classes of traits, one...
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