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Article

Dysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets.

BMC genomics - 24 Sept 2014

Li Guanglei, Jia Qitao, Zhao Jianguo, Li Xinyun, Yu Mei, Samuel Melissa S, Zhao Shuhong, Prather Randall S, Li Changchun

Abstract excerpt

BACKGROUND: Epigenetic modifications (especially altered DNA methylation) resulting in altered gene expression may be one reason for development failure or abnormalities in cloned animals, but the underlying mechanism of the abnormal phenotype in cloned piglets remains unknown. Some cloned piglets in our study showed abnormal phenotypes such as large tongue (longer and thicker), weak muscles, and exomphalos. Here...

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Source

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Identifiers

PMID: 25253444
DOI: 10.1186/1471-2164-15-811
PMCID: PMC4189204

Genes

PLAGL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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