Article
Multi-omic characterization of allele-specific regulatory variation in hybrid pigs.
Nature communications - 3 Jul 2024
Quan Jianping, Yang Ming, Wang Xingwang, Cai Gengyuan, Ding Rongrong, Zhuang Zhanwei, Zhou Shenping, Tan Suxu, Ruan Donglin, Wu Jiajin, Zheng Enqin, Zhang Zebin, Liu Langqing, Meng Fanming, Wu Jie, Xu Cineng, Qiu Yibin, Wang Shiyuan, Lin Meng, Li Shaoyun, Ye Yong, Zhou Fuchen, Lin Danyang, Li Xuehua, Deng Shaoxiong, Zhang Yuling, Yao Zekai, Gao Xin, Yang Yingshan, Liu Yiyi, Zhan Yuexin, Liu Zhihong, Zhang Jiaming, Ma Fucai, Yang Jifei, Chen Qiaoer, Yang Jisheng, Ye Jian, Dong Linsong, Gu Ting, Huang Sixiu, Xu Zheng, Li Zicong, Yang Jie, Huang Wen, Wu Zhenfang
Abstract excerpt
Hybrid mapping is a powerful approach to efficiently identify and characterize genes regulated through mechanisms in cis. In this study, using reciprocal crosses of the phenotypically divergent Duroc and Lulai pig breeds, we perform a comprehensive multi-omic characterization of regulatory variation across the brain, liver, muscle, and placenta through four developmental stages. We produce one of the largest...
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