Article
Pig genome functional annotation enhances the biological interpretation of complex traits and human disease.
Nature communications - 6 Oct 2021
Pan Zhangyuan, Yao Yuelin, Yin Hongwei, Cai Zexi, Wang Ying, Bai Lijing, Kern Colin, Halstead Michelle, Chanthavixay Ganrea, Trakooljul Nares, Wimmers Klaus, Sahana Goutam, Su Guosheng, Lund Mogens Sandø, Fredholm Merete, Karlskov-Mortensen Peter, Ernst Catherine W, Ross Pablo, Tuggle Christopher K, Fang Lingzhao, Zhou Huaijun
Abstract excerpt
The functional annotation of livestock genomes is crucial for understanding the molecular mechanisms that underpin complex traits of economic importance, adaptive evolution and comparative genomics. Here, we provide the most comprehensive catalogue to date of regulatory elements in the pig (Sus scrofa) by integrating 223 epigenomic and transcriptomic data sets, representing 14 biologically important tissues. We...
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