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Article

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

PloS one - 1 Jan 2011

Aster Jon C, Bodnar Nick, Xu Lanwei, Karnell Fredrick, Milholland John M, Maillard Ivan, Histen Gavin, Nam Yunsun, Blacklow Stephen C, Pear Warren S

Abstract excerpt

BACKGROUND: The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, induce T cell acute lymphoblastic leukemia/lymphoma (T-ALL), and maintain T-ALL cell growth and survival. PRINCIPAL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22022427
DOI: 10.1371/journal.pone.0025645
PMCID: PMC3192765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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