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Article

GATA-4 Regulates Bcl-2 Expression in Ovarian Granulosa Cell Tumors

24 Jul 2008

Abstract excerpt

Excessive cell proliferation and decreased apoptosis have been implicated in the pathogenesis of ovarian granulosa cell tumors (GCTs). We hypothesized that transcription factor GATA-4 controls expression of the antiapoptotic factor Bcl-2 and the cell cycle regulator cyclin D2 in normal and neoplastic granulosa cells. To test this hypothesis, a tissue microarray based on 80 GCTs was subjected to...

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PMID: 18653721
DOI: 10.1210/en.2008-0148

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