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Article

High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer.

Cancer science - 1 Jan 2012

Chen Hua-Yun, Zhu Bao-He, Zhang Chang-Hua, Yang Dong-Jie, Peng Jian-Jun, Chen Jian-Hui, Liu Fa-Keng, He Yu-Long

Abstract excerpt

Several studies have found that the promoter CpG island is frequently methylated in gastric cancer. The CpG island methylator phenotype (CIMP) defines concordant methylation of multiple promoter CpG island loci in a subset of gastric cancer. However, the relationship between CIMP and lymph node metastasis in gastric cancer is unknown. Our study aimed to characterize the role of CIMP in lymph node metastasis....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22017425
DOI: 10.1111/j.1349-7006.2011.02129.x
PMCID: PMC11164149

Genes

ALX4
CHCHD10
IGFBP3
NPR1
TMEFF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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