Article
Biological and epidemiological evidence of interaction of infant genotypes at Rs7205289 and maternal passive smoking in cleft palate.
American journal of medical genetics. Part A - 1 Dec 2011
Li Ling, Zhu Gui-Quan, Meng Tian, Shi Jia-Yu, Wu Jun, Xu Xue, Shi Bing
Abstract excerpt
The noncoding SNP rs7205289, located in the microRNA-140 gene has been associated with cleft palate risk. MiR-140 was found to regulate zebrafish palatal development in vivo and its expression level be reduced by environmental smoke exposure in vitro. Therefore, we sought to investigate whether the A allele of rs7205289 and maternal smoke exposure during the first trimester might contribute to cleft palate risk...
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