Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140.

doi:10.1002/ajmg.a.33236

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Article

Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140.

American journal of medical genetics. Part A - 1 Apr 2010

Li Ling, Meng Tian, Jia Zhonglin, Zhu Guiquan, Shi Bing

Abstract excerpt

Nonsyndromic oral cleft is a common developmental malformation of humans. Embryonic development is regulated by microRNAs. MicroRNA-140-5p (miR-140-5p) was found to regulate palatal development. As sequence variants in miRNA genes are likely to affect miRNA expression and/or maturation, we investigated the miRNA-140 gene and identified a SNP (rs7205289: C>A) located in precursor miRNA-140. We carried out a...

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PMID: 20358594
DOI: 10.1002/ajmg.a.33236

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