Article
Variants in miRNA regulome and their association with the risk of nonsyndromic orofacial clefts.
Epigenomics - 1 Jul 2020
Zhu Guirong, Zhang Chi, Wang Yuting, Wang Yuli, Li Dandan, Yu Xin, Zhu Weihao, Fu Chengyi, Lou Shu, Fan Liwen, Ma Lan, Wang Lin, Pan Yongchu
Abstract excerpt
Aim: To investigate the associations between single nucleotide polymorphisms (SNPs) in miRNA regulome and nonsyndromic orofacial clefts. Materials & methods: The associations were evaluated by logistic regression model in stage I (504 cases and 455 controls) and stage II (1500 cases and 1386 controls). Functional experiments including luciferase activity assay, cell apoptosis and proliferation, serum miRNA...
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