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Article

Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge.

Genes & development - 15 Oct 2011

Grau Daniel J, Chapman Brad A, Garlick Joe D, Borowsky Mark, Francis Nicole J, Kingston Robert E

Abstract excerpt

Polycomb group (PcG) proteins are required for the epigenetic maintenance of developmental genes in a silent state. Proteins in the Polycomb-repressive complex 1 (PRC1) class of the PcG are conserved from flies to humans and inhibit transcription. One hypothesis for PRC1 mechanism is that it compacts chromatin, based in part on electron microscopy experiments demonstrating that Drosophila PRC1 compacts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22012622
DOI: 10.1101/gad.17288211
PMCID: PMC3205590

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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