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Article

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2011

Grison Alice, Mantovani Fiamma, Comel Anna, Agostoni Elena, Gustincich Stefano, Persichetti Francesca, Del Sal Giannino

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the gene coding for huntingtin protein. Several mechanisms have been proposed by which mutant huntingtin (mHtt) may trigger striatal neurodegeneration, including mitochondrial dysfunction, oxidative stress, and apoptosis. Furthermore, mHtt induces DNA damage and activates a stress response. In this context, p53 plays a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22011578
DOI: 10.1073/pnas.1106198108
PMCID: PMC3207660

Genes

HIPK2

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