Article
Human cardiac progenitor cell grafts as unrestricted source of supernumerary cardiac cells in healthy murine hearts.
Stem cells (Dayton, Ohio) - 1 Dec 2011
Forte Giancarlo, Pietronave Stefano, Nardone Giorgia, Zamperone Andrea, Magnani Eugenio, Pagliari Stefania, Pagliari Francesca, Giacinti Cristina, Nicoletti Carmine, Musaró Antonio, Rinaldi Mauro, Ribezzo Marco, Comoglio Chiara, Traversa Enrico, Okano Teruo, Minieri Marilena, Prat Maria, Di Nardo Paolo
Abstract excerpt
Human heart harbors a population of resident progenitor cells that can be isolated by stem cell antigen-1 antibody and expanded in culture. These cells can differentiate into cardiomyocytes in vitro and contribute to cardiac regeneration in vivo. However, when directly injected as single cell suspension, less than 1%-5% survive and differentiate. Among the major causes of this failure are the distressing...
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