Article
C-kit+ cardiac progenitors exhibit mesenchymal markers and preferential cardiovascular commitment.
Cardiovascular research - 1 Feb 2011
Gambini Elisa, Pompilio Giulio, Biondi Andrea, Alamanni Francesco, Capogrossi Maurizio C, Agrifoglio Marco, Pesce Maurizio
Abstract excerpt
AIMS: The heart contains c-kit(+) progenitors that maintain cardiac homeostasis. Cardiac c-kit(+) cells are multipotent and give rise to myocardial, endothelial and smooth muscle cells, both in vitro and in vivo. C-kit(+) cells have been thoroughly investigated for their stem cell activity, susceptibility to stress conditions and ageing, as well as for their ability to repair the infarcted heart. Recently,...
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