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Melanoma-derived IL-1 converts vascular endothelium to a proinflammatory and procoagulatory phenotype via NFκB activation.

Experimental dermatology - 1 Sept 2014

Strozyk Elwira A, Desch Anna, Poeppelmann Birgit, Magnolo Nina, Wegener Joachim, Huck Volker, Schneider Stefan W

Abstract excerpt

Spreading of melanoma is associated with efficient extravasation of circulating tumor cells from the vascular system into distant target organs. This process is accompanied and supported by proinflammatory and procoagulatory conditions. In this study, we analysed the ability of human melanoma cell lines to activate endothelial cells (ECs) in vitro. Some melanoma cells, that is, MV3, were shown to trigger an...

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PMID: 25041487
DOI: 10.1111/exd.12505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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