Article
Melanoma and the tumor microenvironment.
Current oncology reports - 1 Sept 2008
Villanueva Jessie, Herlyn Meenhard
Abstract excerpt
Melanoma arises through the accrual of mutations in genes critical for proliferation and survival. Although melanoma had been traditionally conceptualized as a cell-autonomous event, increasing evidence supports the notion that these tumors are not isolated entities but rather depend, interact with, and react to the adjacent microenvironment. Melanoma is composed of not only the malignant cells but also the...
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