Article
Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease.
Neurology - 22 Nov 2005
Maurage C A, Udd B, Ruchoux M M, Vermersch P, Kalimo H, Krahe R, Delacourte A, Sergeant N
Abstract excerpt
Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in...
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