Article
Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia.
PloS one - 1 Jan 2017
Jee Junbae, Mourya Reena, Shivakumar Pranavkumar, Fei Lin, Wagner Michael, Bezerra Jorge A
Abstract excerpt
Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signaling via its Cxcr2 receptor have been linked to bile duct injury. Here, we aimed to investigate whether the intestinal microbiome modulates Cxcr2-dependent bile duct...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.