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Article

DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction?

International journal of molecular sciences - 25 Jul 2024

Ferraguti Giampiero, Francati Silvia, Codazzo Claudia, Blaconà Giovanna, Testino Giancarlo, Angeloni Antonio, Fiore Marco, Ceccanti Mauro, Lucarelli Marco

Abstract excerpt

Genetic features of alcohol dependence have been extensively investigated in recent years. A large body of studies has underlined the important role of genetic variants not only in metabolic pathways but also in the neurobiology of alcohol dependence, mediated by the neuronal circuits regulating reward and craving. Serotonin transporter (5-HTT), encoded by the SLC6A4 gene (Solute carrier family 6-neurotransmitter...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39125658
DOI: 10.3390/ijms25158089
PMCID: PMC11311659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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