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Article

Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2012

Zimic Mirko, Fuentes Patricia, Gilman Robert H, Gutiérrez Andrés H, Kirwan Daniela, Sheen Patricia

Abstract excerpt

Pyrazinamide is one of the most important drugs in the treatment of latent Mycobacterium tuberculosis infection. The emergence of strains resistant to pyrazinamide represents an important public health problem, as both first- and second-line treatment regimens include pyrazinamide. The accepted mechanism of action states that after the conversion of pyrazinamide into pyrazinoic acid by the bacterial...

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Identifiers

PMID: 22004792
DOI: 10.1016/j.tube.2011.09.002
PMCID: PMC3269536

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