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Article

Frequency of undetected CYP2D6 hybrid genes in clinical samples: impact on phenotype prediction.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2012

Black John Logan, Walker Denise L, O'Kane Dennis J, Harmandayan Maria

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is highly polymorphic. CYP2D6-2D7 hybrid genes can be present in samples containing CYP2D6*4 and CYP2D6*10 alleles. CYP2D7-2D6 hybrid genes can be present in samples with duplication signals and in samples with homozygous genotyping results. The frequency of hybrid genes in clinical samples is unknown. We evaluated 1390 samples for undetected hybrid genes by polymerase chain reaction...

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Identifiers

PMID: 22004686
DOI: 10.1124/dmd.111.040832
PMCID: PMC3250050

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