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Article

CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer.

Surgery - 1 Apr 2012

Jo Peter, Jung Klaus, Grade Marian, Conradi Lena-Christin, Wolff Hendrik A, Kitz Julia, Becker Heinz, Rüschoff Josef, Hartmann Arndt, Beissbarth Tim, Müller-Dornieden Annegret, Ghadimi Michael, Schneider-Stock Regine, Gaedcke Jochen

Abstract excerpt

BACKGROUND: Locally advanced rectal cancers are treated with preoperative radiochemotherapy (RCT). However, subsets of patients have no benefit from preoperative treatment. Since epigenetic modifications, including DNA methylation, may influence response to neoadjuvant treatment we studied the CpG island methylator phenotype (CIMP) in patients who received a 5-fluouracil based RCT. METHODS: One hundred fifty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22001634
DOI: 10.1016/j.surg.2011.08.013

Genes

BRAF
KRAS
IGF2
NEUROG1
RUNX3
SOCS1

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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