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Article

Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.

International journal of radiation oncology, biology, physics - 1 May 2012

Schirmer Markus Anton, Mergler Caroline Patricia Nadine, Rave-Fränk Margret, Herrmann Markus Karl, Hennies Steffen, Gaedcke Jochen, Conradi Lena-Christin, Jo Peter, Beissbarth Tim, Hess Clemens Friedrich, Becker Heinz, Ghadimi Michael, Brockmöller Jürgen, Christiansen Hans, Wolff Hendrik Andreas

Abstract excerpt

PURPOSE: Transforming growth factor-beta1 is related to adverse events in radiochemotherapy. We investigated TGFB1 genetic variability in relation to quality of life-impairing acute organ toxicity (QAOT) of neoadjuvant radiochemotherapy under clinical trial conditions. METHODS AND MATERIALS: Two independent patient cohorts (n = 88 and n = 75) diagnosed with International Union Against Cancer stage II/III rectal...

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Identifiers

PMID: 22000747
DOI: 10.1016/j.ijrobp.2011.05.063

Genes

TGFB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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