MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.

doi:10.1038/ng.226

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Article

MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.

Nature genetics - 1 Oct 2008

Kopp Jeffrey B, Smith Michael W, Nelson George W, Johnson Randall C, Freedman Barry I, Bowden Donald W, Oleksyk Taras, McKenzie Louise M, Kajiyama Hiroshi, Ahuja Tejinder S, Berns Jeffrey S, Briggs William, Cho Monique E, Dart Richard A, Kimmel Paul L, Korbet Stephen M, Michel Donna M, Mokrzycki Michele H, Schelling Jeffrey R, Simon Eric, Trachtman Howard, Vlahov David, Winkler Cheryl A

Abstract excerpt

The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in populations of African ancestry has been largely unexplained. To identify genetic variants predisposing to idiopathic and HIV-1-associated focal segmental glomerulosclerosis (FSGS), we carried out an admixture-mapping linkage-disequilibrium genome scan on 190 African American individuals with FSGS and 222 controls. We identified a...

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Identifiers

PMID: 18794856
DOI: 10.1038/ng.226
PMCID: PMC2827354

Genes

MYH9

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Related research

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Click a neighbor to travelStep 1 · 12 closest

MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.PMID 18794856Read ↗

Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15.Semantic proximity Read ↗

A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.Semantic proximity Read ↗

Genetics of Focal Segmental Glomerulosclerosis and Human Immunodeficiency Virus–Associated Collapsing Glomerulopathy: The Role of MYH9 Genetic VariationSemantic proximity Read ↗

Susceptibility genes in common complex kidney disease.Semantic proximity Read ↗

Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.Semantic proximity Read ↗

APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy.Semantic proximity Read ↗

Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study.Semantic proximity Read ↗

MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?Semantic proximity Read ↗

MYH9 is associated with nondiabetic end-stage renal disease in African Americans.Semantic proximity Read ↗

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.Semantic proximity Read ↗

Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants.Semantic proximity Read ↗

The spectrum of MYH9-associated nephropathy.Semantic proximity Read ↗

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