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Article

Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15.

Human molecular genetics - 1 May 2010

Nelson George W, Freedman Barry I, Bowden Donald W, Langefeld Carl D, An Ping, Hicks Pamela J, Bostrom Meredith A, Johnson Randall C, Kopp Jeffrey B, Winkler Cheryl A

Abstract excerpt

Admixture mapping recently identified MYH9 as a susceptibility gene for idiopathic focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN) and end-stage kidney disease attributed to hypertension (H-ESKD) in African Americans (AA). MYH9 encodes the heavy chain of non-muscle myosin IIA, a cellular motor involved in motility. A haplotype and its tagging SNPs spanning introns 12-23 were most...

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Share to Glomerulosclerosis, Focal Segmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20124285
DOI: 10.1093/hmg/ddq039
PMCID: PMC2850614

Genes

MYH9

Provenance

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Related research

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Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15.PMID 20124285Read ↗

MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.Semantic proximity Read ↗

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MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?Semantic proximity Read ↗

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