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Article

HER2 codon 655 G-allele is associated with reductions in plasma high-density lipoprotein levels in breast cancer patients treated with tamoxifen.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Dec 2011

Chang Nai-Wen, Chen Dar-Ren, Chen Fei-Na, Lin Chingju, Wu Chen-Teng

Abstract excerpt

BACKGROUND: Retrospective studies have revealed that overexpression of the epidermal growth factor receptor ErbB-2 (HER2) reduced the efficacy of tamoxifen therapy, which is associated with an increased risk for cardiovascular events. The aim of this study was to evaluate the effects of the HER2 I655V polymorphism (ATC/isoleucine to GTC/valine) on lipid profiles after tamoxifen treatment. METHODS: Thirty-four...

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Identifiers

PMID: 21997313
DOI: 10.2130/JIM.0b013e3182354923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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