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Article

Influence of the HER2 Ile655Val polymorphism on trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients: a meta-analysis.

Pharmacogenetics and genomics - 1 Aug 2015

Gómez Peña Celia, Dávila-Fajardo Cristina L, Martínez-González Luis J, Carmona-Sáez Pedro, Soto Pino María J, Sánchez Ramos Jesús, Moreno Escobar Eduardo, Blancas Isabel, Fernández Juan J, Fernández Dámaso, Correa Concepción, Cabeza Barrera José

Abstract excerpt

BACKGROUND: The HER2 655 A>G genetic variant has recently been associated with trastuzumab-induced cardiotoxicity in HER2 breast cancer patients. Considering previous results, the aim of our study was to validate the role of this polymorphism as a predictor of the cardiac toxicity of trastuzumab in breast cancer patients. METHODS: Our study population was composed of 78 HER2 breast cancer patients receiving...

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Identifiers

PMID: 26049584
DOI: 10.1097/FPC.0000000000000149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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