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Article

Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts.

PloS one - 1 Jan 2011

Hakuno Fumihiko, Yamauchi Yoko, Kaneko Gen, Yoneyama Yosuke, Nakae Jun, Chida Kazuhiro, Kadowaki Tatsuhiko, Yamanouchi Keitaro, Nishihara Masugi, Takahashi Shin-Ichiro

Abstract excerpt

Insulin-like growth factors (IGFs) are well known to play essential roles in enhancement of myogenic differentiation. In this report we showed that initial IGF-I signal activation but long-term IGF-1 signal termination are required for myogenic differentiation. L6 myoblast stably transfected with myc-epitope tagged insulin receptor substrate-1, myc-IRS-1 (L6-mIRS1) was unable to differentiate into myotubes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21991327
DOI: 10.1371/journal.pone.0025655
PMCID: PMC3185002

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