Article
DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome.
Human molecular genetics - 1 Nov 2010
Ollikainen Miina, Smith Katherine R, Joo Eric Ji-Hoon, Ng Hong Kiat, Andronikos Roberta, Novakovic Boris, Abdul Aziz Nur Khairunnisa, Carlin John B, Morley Ruth, Saffery Richard, Craig Jeffrey M
Abstract excerpt
Mounting evidence from both animal and human studies suggests that the epigenome is in constant drift over the life course in response to stochastic and environmental factors. In humans, this has been highlighted by a small number of studies that have demonstrated discordant DNA methylation patterns in adolescent or adult monozygotic (MZ) twin pairs. However, to date, it remains unclear when such differences...
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