Article
Dendritic cells derived from HOXB4-immortalized hematopoietic bone marrow cells.
Experimental biology and medicine (Maywood, N.J.) - 1 Nov 2011
Baru Abdul Mannan, Krishnaswamy Jayendra Kumar, Rathinasamy Anchana, Scherr Michaela, Eder Matthias, Behrens Georg M N
Abstract excerpt
Dendritic cells (DCs) are essential for the generation and modulation of cell-mediated adaptive immunity against infections. DC-based vaccination involves transplantation of ex vivo-generated DCs loaded with antigen in vitro, but remains limited by the number of autologous or allogeneic cells. While in vitro expansion and differentiation of hematopoietic stem cells (HSCs) into DCs seems to be the most viable...
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