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Article

Oxidative stress induces overgrowth of the Drosophila neuromuscular junction.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2011

Milton Valerie J, Jarrett Helen E, Gowers Kate, Chalak Salma, Briggs Laura, Robinson Iain M, Sweeney Sean T

Abstract excerpt

Synaptic terminals are known to expand and contract throughout an animal's life. The physiological constraints and demands that regulate appropriate synaptic growth and connectivity are currently poorly understood. In previous work, we identified a Drosophila model of lysosomal storage disease (LSD), spinster (spin), with larval neuromuscular synapse overgrowth. Here we identify a reactive oxygen species (ROS)...

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Identifiers

PMID: 21987827
DOI: 10.1073/pnas.1014511108
PMCID: PMC3198377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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