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Article

Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease.

Inflammatory bowel diseases - 1 Nov 2011

Krupoves Alfreda, Mack David, Seidman Ernest, Deslandres Colette, Amre Devendra

Abstract excerpt

BACKGROUND: Corticosteroids (CS) effectively induce remission in patients with moderate to severe Crohn's disease (CD). However, CS dependence in children is a significant clinical problem associated with numerous side effects. Identification of molecular markers of CS dependence is of paramount importance. The ABCB1 gene codes for P-glycoprotein, a transporter involved in the metabolism of CS. We examined...

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Source

Identifiers

PMID: 21987299
DOI: 10.1002/ibd.21608

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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