Article
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2006
Toulany Mahmoud, Kasten-Pisula Ulla, Brammer Ingo, Wang Shaomeng, Chen Jianyong, Dittmann Klaus, Baumann Michael, Dikomey Ekkehard, Rodemann H Peter
Abstract excerpt
PURPOSE: It is known that blockage of epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K) activity enhances radiation sensitivity of human tumor cells presenting a K-RAS mutation. In the present study, we investigated whether impaired repair of DNA double-strand breaks (DSB) is responsible for the radiosensitizing effect of EGFR and PI3K inhibition in K-RAS mutated (K-RAS(mt)) cells....
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