Article
Development of a highly sensitive method for detection of JAK2V617F.
Journal of hematology & oncology - 10 Oct 2011
Zhao Anna H, Gao Rufei, Zhao Zhizhuang J
Abstract excerpt
BACKGROUND: Ph- myeloproliferative neoplasms (MPNs) represent a heterogeneous group of chronic diseases characterized by increased expansion of hematopoietic cells of the myeloid lineage. JAK2V617F, an activation mutation form of tyrosine kinase JAK2, is found in the majority of patients with MPNs. Studies have demonstrated that JAK2V617F can cause MPNs, and various methods have been developed to detect JAK2V617F...
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