A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.

doi:10.1007/s00259-011-1941-7

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Article

A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.

European journal of nuclear medicine and molecular imaging - 1 Jan 2012

Wanek Thomas, Kuntner Claudia, Bankstahl Jens P, Bankstahl Marion, Stanek Johann, Sauberer Michael, Mairinger Severin, Strommer Sabine, Wacheck Volker, Löscher Wolfgang, Erker Thomas, Müller Markus, Langer Oliver

Abstract excerpt

PURPOSE: One important mechanism for chemoresistance of tumours is overexpression of the adenosine triphosphate-binding cassette transporter P-glycoprotein (Pgp). Pgp reduces intracellular concentrations of chemotherapeutic drugs. The aim of this study was to compare the suitability of the radiolabelled Pgp inhibitors [(11)C]tariquidar and [(11)C]elacridar with the Pgp substrate radiotracer (R)-[(11)C]verapamil...

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PMID: 21983837
DOI: 10.1007/s00259-011-1941-7
PMCID: PMC3684861

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