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Article

High dimensional endophenotype ranking in the search for major depression risk genes.

Biological psychiatry - 1 Jan 2012

Glahn David C, Curran Joanne E, Winkler Anderson M, Carless Melanie A, Kent Jack W, Charlesworth Jac C, Johnson Matthew P, Göring Harald H H, Cole Shelley A, Dyer Thomas D, Moses Eric K, Olvera Rene L, Kochunov Peter, Duggirala Ravi, Fox Peter T, Almasy Laura, Blangero John

Abstract excerpt

BACKGROUND: Despite overwhelming evidence that major depression is highly heritable, recent studies have localized only a single depression-related locus reaching genome-wide significance and have yet to identify a causal gene. Focusing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated individuals using categorical diagnoses, should improve the...

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Identifiers

PMID: 21982424
DOI: 10.1016/j.biopsych.2011.08.022
PMCID: PMC3230692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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