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Article

A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.

PloS one - 1 Jan 2011

Nakaoka Hirofumi, Cui Tailin, Tajima Atsushi, Oka Akira, Mitsunaga Shigeki, Kashiwase Koichi, Homma Yasuhiko, Sato Shinji, Suzuki Yasuo, Inoko Hidetoshi, Inoue Ituro

Abstract excerpt

Genome-wide association studies (GWAS) have yielded novel genetic loci underlying common diseases. We propose a systems genetics approach to utilize these discoveries for better understanding of the genetic architecture of rheumatoid arthritis (RA). Current evidence of genetic associations with R...

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Identifiers

PMID: 21980439
DOI: 10.1371/journal.pone.0025389
PMCID: PMC3182219

Genes

ZAP70

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21980439-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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