Article
Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices.
Biomaterials - 1 Dec 2011
Weber Benedikt, Schoenauer Roman, Papadopulos Francesca, Modregger Peter, Peter Silvia, Stampanoni Marco, Mauri Arabella, Mazza Edoardo, Gorelik Julia, Agarkova Irina, Frese Laura, Breymann Christian, Kretschmar Oliver, Hoerstrup Simon P
Abstract excerpt
Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device fractures. Biodegradable living tissue engineered occluder membranes (TEOMs) could provide autologous thromboresistant implants with growth and remodeling...
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